home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Islet Transplantation For Diabetes: Failing To Deliver?

  December, 21 2006 2:06
your information resource in human molecular genetics
Has the promise of islet transplantation to treat diabetes been fully realised? Not yet, according to a Viewpoint article to be published in the diabetes-themed January 2007 issue of Nature Clinical Practice Endocrinology & Metabolism, in which Piotr Witkowski and Kevan Herold discuss current practice and conclude that the procedure remains far from perfect. They highlight several areas of research that could yield beneficial results for patients.

Type 1 - or insulin-dependent - diabetes mellitus occurs when the insulin-producing islet cells of the pancreas are destroyed by the patient's own immune system. The condition often occurs at a young age and requires life-long treatment with insulin. Islet transplantation aims to replace the damaged cells with healthy donor tissue, allowing recipients to live without daily insulin injections. But as Witkowski and Herold point out, the beneficial effects of islet transplantation are rarely sustained. The procedure is also associated with harmful effects, such as kidney failure, and is not suitable for all patients.

Intensive efforts are underway to improve the outcome for transplant recipients. Shortage of donor tissue is a major hurdle and researchers are seeking alternative sources, such as islet cells grown in the laboratory. Although the long-term benefits of islet transplantation have fallen short of initial expectations of a cure, Witkowski and Herold conclude that the prospects look good as the National Institutes of Health are committed to establishing dedicated islet isolation and resource centres.

Author contact:

Kevan C Herold (Yale University School of Medicine, New Haven, CT, USA)
Email: kevan.herold@yale.edu

Editor contact:

Vicky Heath (Associate Editor, Nature Clinical Practice Endocrinology & Metabolism)
Email: v.heath@nature.com

(C) Nature Clinical Practice Endocrinology & Metabolism press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.