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Boosting Gene Expression On The X

 
  December, 14 2005 11:01
your information resource in human molecular genetics
 
     
A study published in the January issue of Nature Genetics finds that genes present on the X chromosome are expressed at approximately the same level as those found on non-sex chromosomes (or autosomes).

Christine Disteche and Di Nguyen compared the expression levels of genes present on the X chromosome to those found on autosomes. While only one active copy of the X chromosome is present in individual cells, there are two copies of autosomes. This work shows that there is functional dosage compensation for the single copy of genes on the X chromosome, at the level of expression of these genes. While regulation of expression of genes on the X chromosome has been found previously in other animals, including Drosophila, this is the first example of this occurring in mammals including humans.

Author Contact:

Christine Disteche (University of Washington, Seattle, WA, USA)
E-mail: cdistech@u.washington.edu

Abstract available online.

(C) Nature Genetics press release.


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