home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Viruses Need To Make Mistakes To Better Infect Hosts

 
  December, 14 2005 10:56
your information resource in human molecular genetics
 
     
Certain (RNA) viruses that copy their genome too accurately are less infectious than normal viruses, researchers report online this week in Nature. This proves that viruses need to make a certain number of mistakes when copying their genome. Raul Andino and colleagues also show that the infectiousness of a virus is not determined by a single strain. Instead, a virus exists in its host as a group of related sequences or variants. These variants cooperate and need a certain degree of diversity to adapt to different conditions in the infected host, the researchers say.

The team isolated a poliovirus that makes more exact copies of its genome than normal viruses, and found that it was less virulent in infected mice. When the researchers used a chemical to reintroduce errors in the poliovirus genome, the original virulence of the virus was restored.

These results have implications for the development of antiviral drugs that introduce errors into the genome. Such drugs work because too many errors in a virus genome are just as bad as too few. However, viruses resistant to this type of drug typically make too few errors to start with. On the basis of their research, the authors suggest that such drug-resistant viruses would be less virulent and therefore more susceptible to other types of antiviral drugs then normal viruses.

Author contact:

Raul Andino (University of California at San Francisco, CA, USA)
E-mail: andino@itsa.ucsf.edu

Abstract available online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.