news archive December 2004

• Molecule of the Year 2004
  The Molecule of the Year 2004 is the imidazole-4-acetic acid- ribotide (IAA-RP).
  

• Small Variations in Genes Can Determine Risk of Developing Breast Cancer
  Estrogen receptor genes and haplotypes associated with breast cancer risk
  

• Peptide Vaccine Can Produce Complete Remission in Myeloid Leukemia Patients
  Vaccine made from the PR1 peptide, a small part of a protein found on the inside of leukemia cells.
  
• Stem cells of limited use for cardiac muscle repair
  Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle
  
• Research Shows Existing Diabetes Drugs May Kill Multiple Myeloma
  Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands.
  
• Researchers discover new gene in colon cancer
  15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-{beta}-induced suppressor of human gastrointestinal cancers.
  
• Gene vaccine for Alzheimer's disease shows promising results
  Gene Vaccination to Bias the Immune Response to Amyloid-{beta} Peptide as Therapy for Alzheimer Disease
  
• Important Discovery of Gene Involved in Breast and Prostate Cancer
  SEQUENOM's MassARRAY(R) System Identifies Variations in ICAM Genes Impacting the Most Common Cancers in Women and Men
  
• Protein Delivered Via Genetically Engineered Virus Slowed Glioblasoma Multiforme Growth
  Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L)
  

• Gene Therapy Collaboration
  Genzyme Corporation and Applied Genetic Technologies jointly develop novel therapeutics involving gene therapy.
  
• Novel Gene Transfer Prevents Hypertension-Related Enlarged Heart, Cardiac Fibrosis
  Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.
  
• International HapMap Consortium Widens Data Access
  Mapping of Human Genetic Variation Will Speed Search for Disease Genes
  
• Genetic defect confers risk of major depression, resistance to SSRI drug therapy
  Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
  
• New antibiotic target could mean the end of pneumonia
  Streptococcus pneumoniae Isoprenoid Biosynthesis Is Downregulated by Diphosphomevalonate
  
• A New Species Of Amyloid Peptide
  Identification of a New Presenilin-dependent {zeta}-Cleavage Site within the Transmembrane Domain of Amyloid Precursor Protein
  

• A New Approach To ALS Treatment
  A new treatment approach delays the progression of Amyotropic lateral sclerosis (ALS, often called Lou Gehrig's disease) in an animal model.
  
• Fluorescence Reveals Ubiquitination Dynamics
  A new system for the in vivo tracking of protein ubiquitination states offers considerably more detailed kinetic information than earlier techniques.
  
• Promising Early Insight Into HIV Vaccine Research
  A preliminary investigation of a therapeutic vaccine for HIV has shown some promising signs of efficacy in a subset of the treated patients.
  
• Killer Skin
  Researchers report the identification of an antimicrobial protein secreted by the skin, called psoriasin, that preferentially kills the common gut bacterium Escherichia coli.
  
• Malaria Vaccine From GM Parasites
  Large-scale production of an effective malaria vaccine may be possible in future.
  
• An Unexpected Regulatory Role For Seladin-1
  A new component of the mammalian cellular defence mechanism against tumour production is identified.
  
• Common Blood And Immunity Precursor Cell Discovered
  A new study gives the strongest proof yet for the existence of a common origin for both vascular cells and haematopoietic cells.
  
• Role Of Cancer Gene Identified
  Study sheds light on the role of the BCL6 cancer gene.
  
• Mending A Broken Heart
  Researchers have identified a molecule that they believe protects and promotes the survival of heart muscle cells.
  

• Genentech Named No. 1 Employer by Science Magazine
  Top Employers Survey
  
• Life Science Innovation Dependent on Venture Capital, New Report Asserts
  VC Investment in Biotech and Medical Device Companies Accelerates Time to Market, Extends and Improves the Lives of Millions
  
• Scientists Generate Human Islet Precursor Cells in Culture from Cadaveric Insulin-producing Cells
  Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells
  
• Improved Molecular Switch Could Serve as Sensor, Medical Tool
  'Device' Made of Fused Protein Partners Is Shown to Be Reversible and Highly Sensitive
  
• Estrogen-Associated COX-2 Pathways Explain Protection From Heart Disease in Female Mice
  Implications for Chronic Use of COX-2 Inhibitors in Pre-Menopausal Women
  

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