home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Novel Protein Rations Iron

 
  December, 2 2003 7:41
your information resource in human molecular genetics
 
     
Iron is an essential mineral in the human diet because it is needed for the blood cells to carry oxygen. Unfortunately, too much iron accumulates in the bodies of people who have inherited the genetic disorder, hemochromatosis, and this can interfere with the function of many of the body’s essential organs, resulting in some kinds of heart disease and of diabetes. Now, a study reported in the January issue of Nature Genetics identifies a protein important in regulating iron stores in the body.

Dr George Papanikolaou at Laikon General Hospital in Athens with Dr Michael R Hayden and his colleagues at Xenon Genetics and the Department of Medical Genetics and at the University of British Columbia, studied the inheritance of the disease within several affected families in Greece, Canada and France and found that the gene for one particular protein was damaged in many of the affected individuals. The novel protein, Hemojuvelin, modulates the expression of another protein, Hepcidin, that was already known to be involved in controlling iron levels and to be altered in cases of hemochromatosis.

This disorder was recognized in ancient times, and the traditional treatment, blood-letting, led to medieval physicians being known colloquially as “leeches”. Modern treatment also aims to remove the excess iron from the blood, but unfortunately, these therapies can be costly and may cause further complications in patients. The identification of proteins that control iron stores is likely eventually to enable research into novel therapies.

Author Contact:

Michael Hayden
University of British Columbia
Vancouver, Canada
Tel: +1 604 875 3535
E-mail: mrh@cmmt.ubc.ca

Also available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.