home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Arthritic Clue

  December, 2 2003 7:39
your information resource in human molecular genetics
A single mutation in one gene can trigger autoimmune arthritis in mice, according to research in this week's Nature (Vol. 426, No. 6965, 27 Nov 03; pp. 454-460). The study may help us to understand the causes and molecular mechanisms of some forms of human rheumatoid arthritis.

Shimon Sakaguchi and colleagues studied SKG mice, a strain of mice that spontaneously develop chronic arthritis. The animals have a mutation in the ZAP-70 gene that affects T-cell signalling. Reactive T cells that would normally be lost during development remain, triggering joint inflammation.

Rheumatoid arthritis afflicts about 1% of the world population. Four out of 160 human patients tested positive for similar mutations. This suggests that ZAP-70 mutations may trigger rheumatoid arthritis in 2.5% of cases. The cause of the disease at large remains unknown. The study highlights the complex nature of autoimmune diseases. Genetics and the environment are likely to contribute to disease progression, the authors speculate.


Shimon Sakaguchi
Kyoto University and RIKEN, Japan
Tel +81 7 5751 3888
E-mail shimon@frontier.kyoto-u.ac.jp

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.