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Variants Associated with Hearing Loss in Children Receiving Chemotherapy Medication

  November, 19 2009 18:21
your information resource in human molecular genetics

An association between a chemotherapy-induced hearing loss and specific genetic variants has been identified, according to a new study published online in Nature Genetics. The study suggests that these genetic variants may be useful to identify individuals with increased risk of chemotherapy-induced hearing loss, which could help to manage treatment.

Cisplatin is a commonly used chemotherapy drug, although its side-effects include serious hearing loss in 10-25% of adults and 41-61% of children. In order to identify genetic variants that may be associated with increased risk of cisplatin-induced hearing loss, Colin Ross and colleagues analyzed 220 drug-metabolism genes from over 150 children receiving cisplatin chemotherapy. The scientists found that in these children, variants in the genes TPMT and COMT are significantly associated with cisplatin-induced hearing loss.

Further research is needed to determine whether these findings will be useful in guiding treatment options in a clinical setting.

Author contact:

Colin Ross (University of British Columbia, Vancouver, Canada)
E-mail: colinross1@gmail.com

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

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