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Genome-Wide RNAi Screen for Regulators of Aging

  November, 18 2007 20:10
your information resource in human molecular genetics
In the November 15th issue of G&D, Dr. Gary Ruvkun (Harvard Medical School) and colleagues present the first genome-wide RNAi screen to identify genes that normally delay the onset of aging in C. elegans deficient in the insulin signaling component, daf-2. While previous studies have focused upon genes that extend lifespan when inactivated, this study revolves around genes whose function normally declines throughout life and therefore underlie the aging process. The researchers identified roughly 100 new aging genes ­ most of which are conserved in other animals, including humans. Dr. Ruvkun is confident that “Because humans and worms share about half their genes, it is likely that many of the human counterparts to these worm genes are important in human lifespan as well.”

Source: Genes & Development Press Release


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