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In the November 15th issue of G&D, Drs. Devanjan Sikder and Thomas Kodadek (UT Southwestern Medical Center at Dallas) identify that the protein HIF-1 mediates the regulatory effects of the neurotransmitters Orexin A and B on appetite and wakefulness. The scientists show that orexin upregulates HIF1 (both by inducing its transcription and by decreasing the levels of its antagonist, VHL). Dr. Kodadek commented that "HIF1 activity mainly acts to manipulate cellular energy metabolism. So this surprising connection between orexin and HIF-1 argues that narcolepsy, which is a disease of orexin deficiency, is actually a metabolic disease caused by an energy imbalance in neurons."
Source: Genes & Development Press Release
Message posted by: Robin Kimmel
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