home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Lymph Node Swelling Explained

 
  November, 4 2003 9:34
your information resource in human molecular genetics
 
     
Everyone has suffered, at one time or another, from swollen glands or lymph nodes. In the December issue of Nature Immunology, scientists have finally discovered which signals induce this uncomfortable state, in which T cells accumulate in lymph nodes.

Lymph nodes usually swell during microbial infection as a result of T cell entrapment. As such, lymph nodes are the epicenter of the immune system, because certain cells within these structures switch on the T cells and direct them to commence fighting infection. Soman Abraham and colleagues now report that mice with no mast cells (the cells famous for releasing histamine during allergy attacks) did not suffer from swollen lymph nodes when infected with bacteria. When these mice were injected with mast cells, their lymph nodes could swell. Researchers found that mast cells needed be able to produce the immune modulator tumor necrosis factor (TNF). Injection of a chemical compound that activates mast cells also induced lymph node swelling through production of TNF, a swelling accompanied by recruitment of T cells to the lymph node. These results highlight the two-faced nature of mast cells: critical to jump-start our fight against infection, but responsible for our misery during an allergic reaction.

Author contact:

Soman N. Abraham
Duke University Medical Center
Durham, NC, USA
Tel: +1 919 684 3630
E-mail: abrah006@mc.duke.edu

Additional contact for comment on paper:

Stephen J. Galli
Stanford University Medical School
Stanford, CA, USA
Tel: +1 650 723 7975
E-mail: sgalli@stanford.edu

Also available online.

(C) Nature Immunology Press Release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.