news archive November 2003

• Genes Control Severity of Heart Failure, Study Finds
  Researchers have discovered multiple stretches of DNA containing genes that modify the heart's pumping ability and survival with the disease.
  
• Gliomas’ “protein fingerprint”
  Protein patterns of gliomas can be used to classify tumors and predict their aggressiveness.
  
• Scientists Report on Promising New Approaches to Induce Cancer Cell Suicide
  The findings were presented at the International Conference on Molecular Targets and Cancer Therapeutics.
  
• DNA Used to Create Self-Assembling Nano Transistor
  Breakthrough Proves Possible to Use Biology to Create Electronics
  
• Calcium Channels Control Coronary Artery Relaxation
  Novel target for drugs to treat cardiovascular disease.
  
• Researchers Design and Build First Artificial Protein
  Using sophisticated computer algorithms and standard desktop computers, HHMI researchers have designed and constructed a novel functional protein that is not found in nature.
  
• Group Synthesizes Biologically Active Genome of Bacteriophage φX174
  IBEA Researchers Make Significant Advance in Methodology Toward Goal of a Synthetic Genome.
  
• Laboratory launches Hepatitis C database
  The genomic sequence database is the first of two new HCV databases to be made publicly accessible.
  
• Technology for Massively Parallel DNA Amplification
  Enabling technology for miniaturized DNA amplification is described in the journal Electrophoresis
  
• 7 Million Letters, and Counting
  New Technology Will Speed Genome Sequencing
  

• Amersham Licenses Early-Stage Alzheimer's Disease PET Agents from University of Pittsburgh
  Strategy is to identify a lead candidate for clinical evaluation as a PET (Positron Emission Tomography) diagnostic and monitoring agent
  
• Potential Multi-Biomarker Test for Alzheimer’s
  Ciphergen Announces Discovery of a Potential Test using SELDI ProteinChip® Technology
  
• Technique May Identify Novel Disease Genes at a Faster Clip
  New tool to find the RNA targets of proteins involved in neurological diseases.
  
• Cholesterol Lowering Gene Increases Longevity
  Genetic variation in a gene known for playing a key role in lipoprotein production also appears to be significantly overrepresented in centenarians.
  
• Novel DNA-repair Gene Mutation Can Cause Resistance To Cancer Drugs
  Base Excision Repair Enzyme MED1 Mediates DNA Damage Response to Anti-Tumor Drugs and Is Associated with Mismatch Repair System Integrity
  
• PubMed Search by Protein Name
  PubMed Search by Protein Name Available Free at Ariadne Genomics Web Site
  

• NHGRI Funds Next Generation Of Large-Scale Sequencing Centers
  New Efforts Will Build on Success of the Human Genome Project
  
• World’s First Comprehensive Proteomics Map of Multicellular Organism Completed by CuraGen
  Fruit Fly (Drosophila melanogaster) is a Proven Model System for Many Aspects of Human Biology and Drug Development.
  
• Women’s Symptoms are New or Different Prior to Heart Attack
  This study is one of the initial investigations of women's experience with heart attacks, and how this experience differs from men's.
  

• Beyond biology: Simple system yields custom-designed proteins
  Technique could lead to new drugs as well as industrial processes
  
• FDA Issues Guidance on Pharmacogenomics Data
  Guidance intended to ensure that evolving policies are based on the best science; provide public confidence in this new field
  
• FDA Issues Draft Executive Summary of its Assessment of Safety of Animal Cloning
  Current Voluntary Moratorium on Releasing Animal Clones Remains in Effect
  

• Anti-platelet drug blocks bone metastases in mice
  Treatment also slows development of other tumors.
  
• Lymph Node Swelling Explained
  Scientists have finally discovered which signals induce swollen glands, in which T cells accumulate in lymph nodes.
  
• Researchers Define Molecular Basis of Human "Sweet Tooth" and Umami Taste
  Zuker's lab has moved closer to understanding why some people cannot resist the impulses brought on by sweets.
  
• Avoiding 'Horror Autotoxicus'
  Scientists show how regulatory T cells instruct other immune cells to avoid immune cell–mediated attack of one’s own tissues, referred to as ‘horror autotoxicus’ over 100 years ago.
  
• Mice Inherit Resistance To Malaria
  Research showing that mice lacking a metabolic enzyme (pyruvate kinase) are protected from their malaria parasite, suggests that, somewhere in the world, variants of the pyruvate kinase enzyme may be protecting people from malaria.
  
• Fogarty International Center Announces Awards for Global Health Research Initiative Program for New Foreign Investors
  New grants to support the re-entry of young NIH-trained foreign investigators from the developing world to their home countries.
  
• New Genetic Brain Atlas
  Researchers are compiling a new atlas of the mouse brain, with the aim to provide a detailed map of the different cell types in the central nervous system, offering new insights for neuroscientists and developmental biologists.
  
• Drug Hope For Hepatitis C
  A new drug, developed to treat those with hepatitis C, greatly reduced viral load in a small sample of infected patients.
  
• Researchers create 'supersized' molecule of DNA
  Scientists have created an expanded molecule of DNA with a double helix wider than any found in nature.
  
• Birthing Partners For Stem Cells
  The research, which highlights the crucial relationship between stem cells and their local habitat, may yield practical methods for manipulating stem cells and provide a model for the impact of local environment on cell physiology.
  
• Scientists identify novel enzyme with key role in leukemia protein's normal function
  Scientists have discovered an enzyme they say accounts for a cancer-causing protein's Jekyll-and-Hyde personality.
  
• Chromosome 6 In The Spotlight
  The final sequence of chromosome 6, containing over 166 million bases, has been analysed -- the largest human chromosome to be analysed and published so far.
  
• Study Offers New Insight into Rett Syndrome
  The study suggests that in Rett patients, mutations in MeCP2 impair its ability to regulate BDNF, and that BDNF’s subsequent over-expression may cause Rett.
  

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