home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

The Gene-Mapper's Best Friend

 
  October, 3 2007 9:09
your information resource in human molecular genetics
 
     
Genetic variants associated with dominant or recessive disease-related traits in dogs can be mapped efficiently and with high confidence, report two studies published online in Nature Genetics. As dogs and humans have a similar complement of genes, the mapping of disease-associated variants in dogs may make an important contribution to the study of human genetic disease.

There are more than 400 genetically distinct dog breeds. As each breed originated in a small number of founder dogs, there is a limited amount of genetic diversity within each breed. This sort of genome structure is ideal for the rough mapping of genes because it allows one to analyze most of the genome with a limited number of genetic markers. Kerstin Lindblad-Toh and colleagues found small regions of the genome to be associated with two traits by assessing a relatively small number of single-nucleotide polymorphisms (27,000) in only 20 dogs.

The authors identified a genomic region containing only one gene -- MITF -- as responsible for the absence of skin and coat pigmentation in white boxers, which also predisposes them to deafness. They also identified a region associated with the dorsal hair ridge in Ridgeback dogs, which are prone to dermoid sinus, a neural tube defect. In the accompanying paper, Leif Andersson and colleagues carried out fine mapping of the region associated with the Ridgeback hair ridge, and showed that the causative mutation is a duplication containing four different genes-- FGF3, FGF4, FGF19 and ORAOV1.

Author contacts:

Kerstin Lindblad-Toh (Broad Institute of Harvard and MIT, Cambridge, MA, USA)
E-mail: kersli@broad.mit.edu

Leif Andersson (Swedish University of Agricultural Sciences, Uppsala, Sweden)
E-mail: leif.andersson@imbim.uu.se

Abstracts available online:
Paper 1.
Paper 2.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.