Large numbers of adult stem cells can be efficiently obtained from testis, thanks to a newly identified molecule on the cell surface that will allow researchers to tell them apart from non-self-renewing cell types.
Shahin Rafii and colleagues report online in nature that a newly discovered marker, gpr125, flags rapidly multiplying adult spermatogonial progenitor cells and does not appear on differentiated germ-cell counterparts. They developed a system whereby they can use this marker to generate large numbers of stem cells from mouse testicles. These stem-cell populations formed functioning blood vessels in mice, and it has been demonstrated that they convert to cardiac tissue in culture.
Shahin Rafii (Weill Medical College of Cornell University, New York, NY, USA)
Marco Seandel (Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute & Weill Cornell Medical Center, New York, NY, USA) co-author
(c) Nature press release.
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