home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Controlling The Insulin-Degrading Enzyme May Relieve Alzheimer's Disease

 
  October, 13 2006 10:25
your information resource in human molecular genetics
 
     
The structure of an enzyme that degrades insulin and amyloid-beta suggests a possible way to design drugs that combat the abnormal levels of these proteins in sufferers of diabetes or Alzheimer's disease.

Insulin-degrading enzyme (IDE) is unusual because it binds and cleaves diverse substrates. In research to be published online by Nature, Wei-Jen Tang and his colleagues determine the structure of the enzyme in complex with four substrates, including a subunit of insulin or amyloid. They show that the enzyme undergoes a conformational change when it binds its substrate such that the two ends form an enclosed chamber shaped like a triangular prism. Small proteins that do not have significant positive charges at a certain end make better substrates.

Mutations that disrupt the interaction of the two ends of IDE promote the opening of the chamber to substrates and increase the rate of substrate breakdown 40-fold; hence, drugs similarly designed to disrupt the shape of IDE might help clear the accumulation of amyloid-beta that is characteristic of Alzheimer's disease.

CONTACT

Wei-Jen Tang (University of Chicago, IL, USA)
E-mail: wtang@uchicago.edu

Dennis Selkoe (Harvard Medical School, Boston, MA, USA)
E-mail: dselkoe@rics.bwh.harvard.edu

Abstract available online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.