home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Allergy Molecule Identified

 
  October, 26 2004 8:35
your information resource in human molecular genetics
 
     
Researchers have identified a molecule that is involved in mediating allergic reactions, as detailed in the 21 October 2004 issue of Nature (Vol. 431, No. 7011, see pp. 1007-1011).

Phosphoinositide 3-kinases (PI3K) represent a family of intracellular signalling proteins, which control a variety of important cellular functions such as proliferation, apoptosis and migration. Bart Vanhaesebroeck and his team have studied the delta form of the molecule phosphoinositide 3-kinase (PI(3)K) which is released inside mast cells when they encounter allergens. When PI(3)K delta is inactivated, either in mice genetically engineered to lack this protein, or using a chemical to block it from working, the team showed that mast cells released less inflammatory molecules and the mice reacted less to allergens. This paper identifies PI(3)K delta as a key component of an allergic response.

CONTACT

Bart Vanhaesebroeck (Ludwig Institute for Cancer, London, UK)
Tel. +44 20 7878 4066, E-mail: bartvanh@ludwig.ucl.ac.uk

Co-author
Khaled Ali (Ludwig Institute for Cancer, London, UK)
Tel+ 44 20 7878 4102

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.