home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Allergy Molecule Identified

 
  October, 26 2004 8:31
your information resource in human molecular genetics
 
     
Researchers have identified a molecule that is involved in mediating allergic reactions, as detailed in the 21 October 2004 issue of Nature (Vol. 431, No. 7011, see pp. 1007-1011).

Phosphoinositide 3-kinases (PI3K) represent a family of intracellular signalling proteins, which control a variety of important cellular functions such as proliferation, apoptosis and migration. Bart Vanhaesebroeck and his team have studied the delta form of the molecule phosphoinositide 3-kinase (PI(3)K) which is released inside mast cells when they encounter allergens. When PI(3)K delta is inactivated, either in mice genetically engineered to lack this protein, or using a chemical to block it from working, the team showed that mast cells released less inflammatory molecules and the mice reacted less to allergens. This paper identifies PI(3)K delta as a key component of an allergic response.

CONTACT

Bart Vanhaesebroeck (Ludwig Institute for Cancer, London, UK)
Tel. +44 20 7878 4066, E-mail: bartvanh@ludwig.ucl.ac.uk

Co-author
Khaled Ali (Ludwig Institute for Cancer, London, UK)
Tel+ 44 20 7878 4102

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.