Treatments for fever without the adverse side effects of current medication may be on the horizon, suggests a paper in the November issue of Nature Neuroscience. The study identifies a key enzyme in the chemical pathway in the brain that triggers fever, and proposes that drugs targeting this enzyme could provide improved fever control.
In response to inflammation or infection, cells in the blood vessel walls release a chemical called prostaglandin E2 (PGE2), which acts on the brain to induce fever. Current drugs target and inhibit the function of cyclooxygenase, an enzyme involved in the production of prostaglandins, including PGE2. But prostaglandins have a number of functions and blocking them all might be the reason that some current drugs cause unwanted side effects. Researchers have now identified another enzyme, mPGES-1, involved more specifically in the production of PGE2. When the researchers injected mice that lacked the mPGES-1 gene with a toxin to induce fever, PGE2 levels did not increase, and body temperature was normal. Thus, mPGES-1 appears to be an important ‘switch’ for activating the fever response.
University of Linkoping, Sweden
Tel: +46 13 223193
Also available online.
(C) Nature Neuroscience press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...