home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Clue To HIV Vaccine Success

  September, 20 2007 7:19
your information resource in human molecular genetics
A neutralizing human antibody has previously been shown to protect against HIV in a monkey model. Dennis R. Burton and colleagues report in Nature that the protective effect is not only due to the antibody's neutralizing activity, that is, its ability to block viral entry into target cells, but also to antiviral responses due to the antibody's ability to bind to Fc receptors on effector cells. Antibody-activated effector cells can act against both free virus and against virus-infected cells.

The study implies that prevention of HIV infection may require activity against both free virions and infected cells, and that vaccine efficacy may be crucially dependent on its ability to elicit a combination of antibody and cell-mediated immunity.


Dennis R. Burton (The Scripps Research Institute, La Jolla, CA, USA)

E-mail: burton@scripps.edu

John Mascola (NIH, Bethesda, MD, USA)

E-mail: jmascola@mail.nih.gov

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.