home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

A Novel Trick Of An Old Friend

 
  September, 13 2006 10:05
your information resource in human molecular genetics
 
     
A form of the well-known protein, p53, appears to promote brain nerve fibre regeneration in a mouse model. Simone Di Giovanni and colleagues, publishing in the EMBO Journal, believe this could encourage new routes in the search for treatments for disorders such as spinal cord injury, brain trauma or possibly Alzheimer's and Parkinson's.

Since its discovery in 1979, mutations in the tumour suppressor protein, p53, have been described in a huge variety of human malignancies. In intact cells, p53 senses damage and controls the general fate of the cell in response to these environmental inputs. It is this special function that researchers all over the world try to restore in the quest to cure cancer.

Searching for the regulatory mechanisms of proteins known to be crucial for regeneration and recovery of cells within the brain, the team identified control regions, which could be recognised by p53. They then showed that p53 does indeed bind to these control elements and regulate the activity of corresponding proteins, thereby contributing to nerve cell outgrowth and axonal, or nerve fibre regeneration. They report, however, that only a specific form, namely lysine 320-acetylated p53, was able to exert this function.

Important information is still missing, for instance, how is this particular modification of p53 induced, or which of the known p53 modifying enzymes is employed here? The news does, however, open unexpected directions for possible therapeutic interventions after peripheral or central nervous system injuries.

Author contact
Simone Di Giovanni (Hertie Institute for Clinical Brain Research, Tuebingen, Germany)
E-mail: simone.digiovanni@medizin.uni-tuebingen.de

Editorial contact
Thomas Schwarz-Romond (EMBO, Heidelberg, Germany)
E-mail: schwarzr@embl.de


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.