home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

The Spiniest Aspect Of Amyloid Formation

 
  September, 21 2005 7:24
your information resource in human molecular genetics
 
     
Amyloid fibrils are found in a number of neurodegenerative disorders, including Alzheimer's and prion-based diseases. These fibrils are rope-like structures formed by linked protein molecules. David Eisenberg and his colleagues report in the 08 Sept. 2005 issue of Nature (Vol. 436, No. 7056, pp. 266-269) how these proteins can "zip up" without losing their ability to function properly.

The accepted paradigm has been that native proteins undergo wholesale refolding into a generic amyloid structure. Using a 'designer' enzyme that can form amyloids, Eisenberg and his team now show that this model might need modifying. The enzyme simply opens, and the amyloid spine forms from one segment of its polypeptide chain while the core of the protein remains folded. The one polypeptide segment missing after opening can be complemented - through a domain-swap with the neighbouring protein - to form active enzyme again.

"Because of their large size and variable length, amyloid fibres confound traditional methods used to determine protein structure. Sambashivan et al. use an ingenious approach to show that the protein in the fibre has a native structure," writes Andrew Miranker in a related News and Views piece.

CONTACT:

David Eisenberg (UCLA, Los Angeles, CA, USA)
Tel: +1 310 825 3754; E-mail: david@mbi.ucla.edu

Andrew Miranker (Yale University, New Haven, CT, USA)
Tel: +1 203 432 8954; E-mail: andrew.miranker@yale.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.