home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Nature INSIGHT Review Article: The Challenges Of Hepatitis C

 
  August, 24 2005 8:51
your information resource in human molecular genetics
 
     
Combinations of multiple drugs will be required for the successful treatment of hepatitis C virus (HCV), according to a review article in a special Insight in the August 18, 2005 issue of Nature (Vol. 436, No. 7053).

Raffaele De Francesco and Giovanni Migliaccio argue that the chronic nature of HCV infection means that the disease, which is estimated to affect 170 million people worldwide, will continue to be a global health threat for years to come.

The biggest concern in the field of HCV treatment is of the virus becoming drug-resistant, which it can do quickly, owing to the low fidelity of HCV replication. The authors describe the problems faced by a lack of small-animal models for HCV and, until recently, an inability to infect cultured cells with the virus. Looking to the future, De Francesco and Migliaccio argue that RNA interference, nucleic-acid-based antiviral agents and inhibitors of important molecules should all be investigated as the basis of new treatments.

Several new drugs are close to the clinical trial stage, and it is vital to their success that they not only combat HCV but prevent the emergence of new mutant strains of the disease.

Elsewhere in the Insight, Michael Houghton and Sergio Abrignani investigate the prospects for a vaccine that have recently emerged, following the discovery of natural immunity to HCV and the efficacy of vaccine treatment in chimpanzee models. This knowledge, coupled with studies showing that some individuals can clear the virus while others need antiviral treatment, could help to improve the outcome of work towards vaccines. David Bowen also looks at the immunological response to the virus, and in particular, the role of T cells.

The Insight also features reviews on how HCV combats immune responses, new systems for culturing the virus, past and future directions for antiviral therapies, and the need for liver transplantation in HCV patients.

Free full access to the INSIGHT Articles available here: FREE ACCESS.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.