news archive August 2005

• Hand Held Medical Lab
  Hand-held Device Would Test Residents of Remote Villages for Malaria, Other Endemic Diseases.
  

• Aftermath of Miscarriage: Drug Offers Alternative to Surgical Treatment
  Misoprostol, a drug first used to reduce the risk of stomach ulcers in people taking certain types of painkillers can also be used in place of surgical vacuum aspiration.
  
• The brain chemical for cravings?
  Orexin, a brain chemical involved in feeding behavior, arousal, and sleep, may also plays a role in reward function and drug-seeking behavior.
  

• Neurons That Know The Odds
  Study reports that neurons in a part of the brain called the posterior cingulate cortex represent the riskiness of choices in monkeys.
  
• New Treatment Against SARS Effective In Monkeys
  Small interfering RNAs, short RNA sequences that can inhibit gene expression, are effective against infection with the severe acute respiratory syndrome (SARS) virus in monkeys.
  
• Study Of Lymph Vessels Makes A Leap
  Scientists present tadpoles of the African clawed frog Xenopus laevis as a model for investigating the development of lymph vessels.
  
• Avoiding New Food Allergens
  Discussions on the steps taken to detect new food allergens from genetically modified plants and the limitations of these safeguard measures.
  
• Passport For Emigrating Immune Cells
  Two reports suggest exit of immune cells from peripheral tissues does not passively occur but requires the expression of a specialized receptor called CCR7.
  
• Unwinding Fanconi Anemia
  Five studies provide insight into the mechanism underlying the chromosomal instability that characterizes the disease Fanconi anemia.
  
• Seeing Cathepsin
  The activity of cathepsins, cysteine proteases involved in a number of stages of tumor development, is visualized in a cellular model of a tumor microenvironment.
  
• Viewing Receptor Clusters In A Heart Beat
  Researchers report the use of a high-resolution imaging technique to visualize heart cell receptor clusters for the first time.
  
• Antibiotic Assembly Line
  Scientists have turned bacteria into miniature factories for producing novel types of antimicrobial compounds at unprecedented rates.
  
• Nature INSIGHT Review Article: The Challenges Of Hepatitis C
  Combinations of multiple drugs will be required for the successful treatment of hepatitis C virus (HCV).
  
• Hair And Telomere
  Scientists describe how activating the protein in skin cells results in rapid hair growth.
  
• A Newly Discovered Pathway To Haemoglobin Production
  A study provides a new link between two fundamental processes - haem production and the formation of iron-sulphur clusters on proteins.
  
• A Rewarding View On Orexin Cells
  Activation of neurons that contain the neurotransmitter orexin in the lateral hypothalamus is proportionally linked to food- and drug-seeking behaviours in rats.
  

• Boosting The BCG Vaccine To Beat Tuberculosis
  Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin.
  
• Scientists crack 40-year-old DNA puzzle and point to ‘hot soup’ at the origin of life
  A new theory that explains why the language of our genes is more complex than it needs to be also suggests that the primordial soup where life began on earth was hot and not cold, as many scientists believe.
  
• A Powerful New Tool for Decoding Gene Functions in Mammals and Man
  Efficient Transposition of the piggyBac (PB) Transposon in Mammalian Cells and Mice.
  
• Researchers Find BRCA1 Tumor Suppression Nullified By Cyclin D1
  The results reaffirm cyclin D1 as a candidate target for molecular therapeutic control of breast tumor development.
  
• Scientists zero in on drugs' sweet spots
  Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.
  
• Micro RNAs Play Role In Egg Making
  Evidence that miRNAs are involved in oogenesis
  
• Scientists Discover Genetic Pathway Responsible For Breast Cancer Cell Growth
  Location analysis of estrogen receptor {alpha} target promoters reveals that FOXA1 defines a domain of the estrogen response.
  

• Link Between Alcohol and Certain Cancers
  Acetaldehyde, a suspected carcinogen formed as the body metabolizes alcohol, can react with polyamines to trigger DNA damage.
  

• New evidence that the dopamine transporter gene may be involved in the aetiology of ADHD
  Association found with a single-nucleotide polymorphism in the 3'untranslated-region of DAT1
  

• Helping Smokers Quit
  Study reveals how methoxsalen, a drug that has been clinically proven to decrease smoking, interacts with and blocks the action of a protein that breaks down nicotine.
  
• Interfering With HIV
  Scientists have found a molecule that interferes with the formation of infectious Human immunodeficiency virus (HIV) particles.
  
• Avoiding Regret In The Brain
  A functional imaging study shows that a brain region called the medial orbitofrontal cortex mediates the influence of emotions like regret on decision-making.
  
• Protein -- Pure And Simple
  A new purification method offers scientists an efficient and budget-friendly tool for large scale protein production.
  
• Diagnostic Methods Promise Smallpox Detection
  Researchers report on a diagnostic method that could be used to accurately detect smallpox.
  
• Taking Complements Away
  Scientists have identified a staphylococcal protein that can block the complement cascade aiding the bacteria to escape detection by the immune system.
  
• Targeting The Transcription Start Site Of DNA
  A new method of silencing gene expression is reported.
  
• Cancer Suppression Puts Cells Under Arrest
  Four studies show that senescence does indeed get induced in vivo to put the break on cancer-causing genes.
  
• Genes Responsible For Breast Cancer Metastasis Identified
  Study helps to shed some light on the genes that mediate breast cancer metastasis to the lung but not other organs.
  
• A Structure Of Antidepressants' Binding Sites
  Scientists have now captured the crystal structure of a bacterial sodium/chloride-dependent transporter, which moves leucine across membranes.
  

• 'Smart' Bio-nanotubes Developed; May Help In Drug Delivery
  Cationic liposome-microtubule complexes: Pathways to the formation of two-state lipid-protein nanotubes with open or closed ends
  
• Family Of Life-extending Genes Discovered
  Discovery Sheds Light On How A Low-calorie Diet Extends Lifespan
  
• A Step Toward The $1,000 Personal Genome Using Readily Available Lab Equipment
  The theoretical price of having one's personal genome sequenced just fell from the prohibitive $20 million dollars to about $2.2 million
  

• Genetic basis of long-term memory identified in humans
  Single nucleotide changes in the PRNP gene linked to long-term memory in a sample of 354 healthy individuals
  

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