home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

A Newly Discovered Pathway To Haemoglobin Production

 
  August, 24 2005 8:26
your information resource in human molecular genetics
 
     
Haemoglobin proteins in red blood cells have a vital role in delivering oxygen to tissues throughout the body. A decrease in the production of haemoglobin, or the haem molecules embedded within haemoglobin, can lead to anaemia. A study in the August 18, 2005 issue of Nature (Vol. 436, No. 7053, pp. 1035-1039) provides a new link between two fundamental processes - haem production and the formation of iron-sulphur clusters on proteins.

Leonard Zon and his colleagues have shown that the anaemia found in a zebrafish mutant called shiraz is caused by a defect in the glutaredoxin 5 gene. This gene is essential in yeast for the assembly of iron-sulphur clusters. The research team found that this gene performs the same function in zebrafish, and that the loss of these assembled iron-sulphur clusters also prevented the production of haem molecules in mutant zebrafish. Based on these results, they suggest that a deficiency in iron-sulphur clusters could be an overlooked cause of anaemia in humans.

CONTACT

Leonard I. Zon (HHMI, Harvard Medical School, Boston, MA, USA)
E-mail: zon@enders.tch.harvard.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.