Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, have identified a gene that plays an important role in preventing tumors in mice. In a study published in the Aug. 8, 2003, issue of the journal Cell*, the researchers demonstrate that reducing or eliminating the H2AX gene in mice that lack p53, a well-known tumor suppressor gene, causes an increase in the number of tumors that develop.
*Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, et al. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 2003;114:371-383.
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