Spermicide Might Favour HPV Infection

HPV is the most common sexually transmitted virus and causes virtually all cases of cervical cancer. However, studying its genital transmission has been difficult owing to the lack of a suitable animal model. In the present study, John Schiller and colleagues developed a mouse model of vaginal infection with HPV that mirrors the early phase of human infection. Using this model, they found that nonoxynol-9, a molecule widely used in vaginal spermicides, greatly increased susceptibility to HPV infection. By contrast, carrageenan -- a molecule present in some vaginal lubricants -- prevented infection even in the presence of nonoxynol-9, suggesting that carrageenan might serve as an effective topical HPV microbicide.

Author contact:

John Schiller (National Cancer Institute, NIH, Bethesda, MD, USA)
E-mail: schillej@mail.nih.gov

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza