home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Hsp90 Inhibitors Allow Small Cell Lung Cancer To Die

  July, 12 2007 8:23
your information resource in human molecular genetics
Scientists describe the role played by a protective protein called Hsp90 in maintaining the malignant state of small cell lung cancer cells, in a report in the August 2007 issue of Nature Chemical Biology.

Hsp90 is a chaperone protein that helps cellular proteins fold and mature. This protective function can also stabilise oncogenic proteins in cancer cells, exacerbating their cancer-causing potential. Gabriela Chiosis and colleagues show that Hsp90 plays a particularly important role in small cell lung cancer (SCLC) cells by inhibiting apoptosis, the programmed destruction of cells. The results in SCLC cell lines help explain why SCLC tumours are so malignant, resulting in relapses even after responding well to chemotherapy.

Various selective compounds identified by the authors are potential candidates for treating SCLC patients in the future, since they allow SCLC to overcome their apoptosis defects. Further studies should help to explore this possibility.

Author contact:

Gabriela Chiosis (Memorial Sloan-Kettering Cancer Center, New York, NY, USA)
E-mail: chiosisg@mskcc.org

Abstract available online.

(C) Nature Chemical Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.