|
|
|
A resource that could change the very nature of genetic research on fruitflies is published in Nature. Barry Dickson and colleagues present a library of transgenic flies in which genes can be inactivated by RNA interference (RNAi), and which covers 88% of the protein-coding genes in the fruitfly genome. This opens up the possibility of analysing gene functions in any tissue and at any stage of the Drosophila lifespan.
Systematic approaches to RNAi are common for investigating key functions of genes during embryonic development. But many genes are vital both in early development and later in the lifespan, and previous approaches knock out the gene in embryogenesis and leave the model devoid in later life. Fruitflies represent an ideal model in which gene function can be disrupted at any time - allowing researchers the option of analysing the function further down the developmental line. CONTACT Barry Dickson (Institute of Molecular Pathology, Vienna, Austria)
E-mail: dickson@imp.ac.at (C) Nature press release.
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|