home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Chromatin Modification Maps And Cell State

  July, 12 2007 8:12
your information resource in human molecular genetics
The generation of genome-wide maps of chromatin modification in mammalian cells is described in a paper published online by Nature. Using a technique known as single-molecule-based sequencing, Eric Lander and colleagues produced 'chromatin-state' maps that provide a rich source of information about cell state, and yield insights beyond what is typically achieved using other methods.

Although they have essentially identical genomes, the different cell types in a multicellular organism maintain markedly different behaviours that persist over extended periods. Previous research suggests that cellular state may be closely related to chromatin state - that is, modifications to histones and other proteins that package the genome. In the present study, the authors used single-molecule-based sequencing technology to construct chromatin-state maps for mouse embryonic stem cells and two other more developmentally advanced cell types, revealing the genome-wide distribution of important chromatin modifications. This allowed them to distinguish between genes that were active, poised for activation or stably repressed, reflecting cellular state and developmental potential.

The authors propose that their study provides a framework for applying comprehensive chromatin profiling towards characterizing diverse mammalian cell populations, including situations of abnormal development such as in cancer.

Author contact:

Eric S. Lander (Broad Institute of MIT and Harvard, Cambridge, MA, USA)
E-mail: lander@broad.mit.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.