home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Cold Sore Virus Can Evade The Immune System

 
  July, 20 2006 7:54
your information resource in human molecular genetics
 
     
A newly identified method deployed by viruses to escape the immune system is reported in the August 2006 issue of Nature Immunology. Many strategies devised by viruses to 'hide' or 'escape' have been devised and these results describe another, previously unknown mechanism.

Immune cells called natural killer T cells are important in detecting and containing herpes simplex virus 1 (HSV-1) infections, which cause cold sores. HSV-1 particles are 'displayed' on the surface of infected cells, enabling the natural killer T cells to distinguish between infected and uninfected cells. The molecule CD1d, which presents HSV-1 particles, constantly moves in a loop from the cell surface to the interior of the cell to sample and display of the contents of infected cells to natural killer T cells.

Peter Cresswell and colleagues demonstrate that HSV-1 blocks this loop; specifically preventing CD1d molecules from returning back to the cell surface. As a result, HSV-1-infected cells appear to be uninfected and are therefore nearly 'invisible' to natural killer T cells. Precisely how the virus blocks CD1d looping remains to be determined. However, these results emphasize an additional mechanism by which viruses can escape immune detection.

Author contact:

Peter Cresswell (Yale University, New Haven, CT, USA)
E-mail: peter.cresswell@yale.edu

Abstract available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.