news archive July 2006

• New Genomes to be Targetted for Sequencing
  United States' National Human Genome Research Institute Large Scale Sequencing Research Network adds more animal genomes to it's To Do List.
  
• New Blood Test for the Prediction and Complications of Sickle Cell Disease
  Brain natriuretic peptide or BNP is a hormone whose levels might also correlate with the severity of pulmonary hypertension and risk of death in sickle cell patients.
  

• Brain-Machine Interfaces - Recent Advances
  Nature Web Focus includes exclusive interviews and video footage of experiments, alongside papers that paved the way for these recent advances.
  
• Cold Sore Virus Can Evade The Immune System
  A newly identified method deployed by viruses to escape the immune system is reported.
  
• Alternative Genetic Cause Of Devastating Dementia
  Two groups of neuroscientists have uncovered a mutation that can cause frontotemporal dementia (FTD).
  
• Making Cancer Stem Cells
  Researchers show how cancer-triggering oncogenes can allow blood cells to acquire this ability and thus become leukaemia stem cells.
  
• Surprisingly, DNA Has Trouble Unwinding
  If you stretch the helical structure of DNA, it actually winds itself more tightly.
  
• Co-Transplantation Of Bone Marrow Stromal Cells Transduced With IL-7 Gene Enhances Immune Reconstitution After Allogeneic Bone Marrow Transplantation
  The use of MSC-IL-7 cells may be therapeutically useful for enhancing immune reconstitution without aggravating graft-versus-host disease (GVHD) in allo-BMT mice.
  
• Plasmid-Mediated VEGF Gene Transfer Induces Cardiomyogenesis And Reduces Myocardial Infarct Size In Sheep
  VEGF gene transfer could also modify the evolution of experimental myocardial infarct.
  
• A Linkage of Two JNK Isoforms With Obesity and Insulin Resistance
  The total activity of two isoforms of c-Jun N-terminal kinase is correlated with development of obesity and insulin resistance.
  

• Gender: Its not how you look, its how you express yourself
  A UCLA study finds that the same genes express differently in males and females; discovery may explain gender gap in disease risk and drug response
  

• Prion Disease Infectivity May Yield New Mouse Model for Heart Diseases
  Laboratory mice infected with the agent of scrapie show high levels of the scrapie agent in their heart several hundred days after being infected in the brain yielding a potential animal model to study heart amyloidosis.
  
• The Risk for Melanoma Possibly Inherited
  Scientists Identify an Inherited Gene That Strongly Affects Risk for the Most Common Form of Melanoma
  

• Hearing’s Missing Link May Be a Protein Tied to Usher Syndrome
  Protocadherin-15 is a likely player in the split-second reaction in which sound is converted into electrical signals. The findings may help elucidate why some people temporarily lose their hearing after being exposed to loud noise.
  
• Dopamine drug leads to neuronal replacement: a cure for Parkinson's Disease?
  In preliminary results, researchers have shown that a drug, which mimics the effects of dopamine, causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD).
  
• Regulation of Microglial Neurotoxicity
  CX3CR1 signaling pathway is implicated in three models involving neurotoxicity: systemic inflammation, Parkinson’s disease, and ALS.
  

• Free Access To Nature Protocols
  Available Online Till The End Of July.
  
• Gene Transfer Of RANTES And MCP-1 Chemokine Antagonists Prolongs Cardiac Allograft Survival
  Research suggests a role for anti-chemokine gene therapy as an adjuvant therapy in heart transplantation.
  
• Sequencing Of The Reannotated Lmnb2 Gene Reveals Novel Mutations In Patients With Acquired Partial Lipodystrophy
  Authors sequence LMNB2 as a candidate gene in nine white patients with acquired partial lipodystrophy (APL, also called "Barraquer-Simons syndrome").
  
• Localization Of Candidate Regions For A Novel Gene For Kartagener Syndrome
  Research data provide a basis for the identification of a novel gene implicated in Kartagener syndrome.
  
• Exploring The Logic Of Neural Cell Development
  Sceintists report on a revolutionary technology to explore and identify the complex molecular signals that determine the fate of precursor cells of the human brain.
  
• Science And Security In The Twenty-First Century
  The 2006 special issue of EMBO Reports on Science & Security covers the social, economic and ethical impact of dual-use research in the life sciences on society and vice versa.
  
• Genes, Not Environment Determine Physical Activity Levels In Children
  'Activity genes' that children are born with influence their physical activity levels more than environmental factors.
  
• Understanding The Causes Of Obesity
  The amount of sleep a person has, or their exposure to air conditioning may be as important causes of obesity as diet and exercise.
  
• Clostridium difficile Genome
  The genome sequence of Clostridium difficile, a major hospital acquired human pathogen, is published.
  
• A Malaria Drug For Underdeveloped Countries
  Scientists have found a drug that can be used to control malaria infection.
  
• New Class Of Cancer Therapeutic
  Scientists have created a new class of cancer drug that combines the targeting strength of one type of ribonucleic acid (RNA) therapy with the therapeutic potency of another.
  
• Stem Cells: Hopes And Realities
  Insight articles provide an overview of the field of stem cell biology and its promise.
  
• Stimulating Stem Cells Fights Stroke Damage
  Scientists show that stimulating a specific signalling pathway in the neural stem cells of rat brain can help the animals recover movement after a simulated stroke.
  
• Thymus Bipotent Precursor Cells Found
  Researchers have discovered that a single precursor cell can form both major cell types of the thymus.
  
• T-Cell Link To Cancer
  A link has been found between a particular type of gastrointestinal cancer and T-cell functioning.
  

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