Allogeneic bone marrow transplantation (allo-BMT) is followed by a period of profound immune deficiency, which results in significant susceptibility to infections and limits the extensive application of this approach in clinic. Dr. S. Xie’s group transduced human interleukin-7 (IL-7) gene into donor-derived bone marrow stromal cells (MSCs) using adenovirus vector, and transplanted this gene-engineered MSCs (MSC-IL-7) into lethally irradiated C57BL/6 mice to investigate their effects on immune reconstitution following allo-BMT. Thus, the use of MSC-IL-7 cells may be therapeutically useful for enhancing immune reconstitution without aggravating graft-versus-host disease (GVHD) in allo-BMT mice. Their research is described in Gene Therapy (Vol. 13, pp. 1178–1187).
Dr. S. Xie, Department of Immunology, Peking University Health Center, 38 Xuyuan Road, Beijing 100083, People's Republic of China.
Abstract available online.
(C) Gene Therapy.
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