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Co-Transplantation Of Bone Marrow Stromal Cells Transduced With IL-7 Gene Enhances Immune Reconstitution After Allogeneic Bone Marrow Transplantation

 
  July, 20 2006 7:28
your information resource in human molecular genetics
 
     
Allogeneic bone marrow transplantation (allo-BMT) is followed by a period of profound immune deficiency, which results in significant susceptibility to infections and limits the extensive application of this approach in clinic. Dr. S. Xie’s group transduced human interleukin-7 (IL-7) gene into donor-derived bone marrow stromal cells (MSCs) using adenovirus vector, and transplanted this gene-engineered MSCs (MSC-IL-7) into lethally irradiated C57BL/6 mice to investigate their effects on immune reconstitution following allo-BMT. Thus, the use of MSC-IL-7 cells may be therapeutically useful for enhancing immune reconstitution without aggravating graft-versus-host disease (GVHD) in allo-BMT mice. Their research is described in Gene Therapy (Vol. 13, pp. 1178–1187).

Correspondence:

Dr. S. Xie, Department of Immunology, Peking University Health Center, 38 Xuyuan Road, Beijing 100083, People's Republic of China.
E-mail: xiess@bjmu.edu.cn

Abstract available online.

(C) Gene Therapy.


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