Vascularized organ allografts are rapidly destroyed by host immune cells that are recruited along chemokine gradients. Among chemokines, Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES) CC chemokine ligand (CCL5) and monocyte chemoattractant protein (MCP)-1 (CCL2) are upregulated in rejecting cardiac allografts. To antagonize these chemokines, the authors constructed adenoviral vectors expressing NH2-terminal deletion (8ND) mutants of the respective genes.
Their results are published in Gene Therapy (Vol. 13, pp. 1104–1109).
The results suggest a role for anti-chemokine gene therapy as an adjuvant therapy in heart transplantation.
Professor G Vassalli, Department of Cardiology, Centre Hospitalier Universitaire Vaudois (CHUV), rue du Bugnon, 1011 Lausanne, Switzerland.
Abstract available online.
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(C) Gene Therapy.
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