Vascularized organ allografts are rapidly destroyed by host immune cells that are recruited along chemokine gradients. Among chemokines, Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES) CC chemokine ligand (CCL5) and monocyte chemoattractant protein (MCP)-1 (CCL2) are upregulated in rejecting cardiac allografts. To antagonize these chemokines, the authors constructed adenoviral vectors expressing NH2-terminal deletion (8ND) mutants of the respective genes.
Their results are published in Gene Therapy (Vol. 13, pp. 1104–1109).
The results suggest a role for anti-chemokine gene therapy as an adjuvant therapy in heart transplantation.
Professor G Vassalli, Department of Cardiology, Centre Hospitalier Universitaire Vaudois (CHUV), rue du Bugnon, 1011 Lausanne, Switzerland.
Abstract available online.
Table of contents with links to abstracts (free for everyone) and full text (for members only) available at TOC online.
(C) Gene Therapy.
Posted by: Tressie Dalaya
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking