home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

T-Cell Link To Cancer

 
  July, 5 2006 6:44
your information resource in human molecular genetics
 
     
A link has been found between a particular type of gastrointestinal cancer and T-cell functioning. The discovery, reported in the 22 June 2006 issue of Nature (Vol. 441, No.7096, pp. 1015-1019), may have implications for patient treatment and aid the development of new therapies.

Children with the syndrome familial juvenile polyposis (FJP) develop gastrointestinal polyps that can sometimes become cancerous. Around half of all patients carry an inherited mutation in one copy of the SMAD4 gene, and it's thought that cancer develops if the remaining copy becomes inactivated in the epithelial cells that line the gastrointestinal tract.

John Letterio and colleagues studied mice in which the Smad4 gene was deleted in specific cell types. When the gene was deleted in epithelial cells, mice did not develop cancer. But when the gene was deleted in T cells, which play a role in the immune system, mice developed epithelial cancers throughout the gastrointestinal tract.
Although the role of T cells in FJP has yet to be determined, the findings show that a genetic alteration in one cell type can induce cancer formation in a different tissue, increasing our understanding of the role of the microenvironment in tumour development.

CONTACT
John Letterio (Case Western Reserve University, Cleveland, OH, USA)
E-mail: John.Letterio@case.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.