home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Tickling Nerves Prevents Inflammation

  July, 26 2005 11:20
your information resource in human molecular genetics
Stimulation of nicotinic acetylcholine receptors (nAChRs), which are found on both nerves and immune cells, can initiate a program that shuts down the inflammatory machinery of immune cells, according to a paper in the August issue of Nature Immunology.

Such a trigger can be exploited to prevent inflammation. This new work adds to accumulating evidence that suggests the nervous system is intimately linked to the immune system.

Macrophages are immune cells that produce large amounts of proteins and chemicals to produce inflammatory effects. Wouter de Jonge and colleagues find that triggering nAChRs on macrophages sets off certain small molecules known as Jak2 and STAT3 in the cells to reduce inflammation by decreasing the production of offending proteins. To demonstrate the usefulness of this finding, they stimulate a major nerve (the vagus nerve) that links the brain to the gut in a mouse experiment that imitates inflammation after intestinal surgery. Normally, intestinal surgery can induce severe inflammation that leads to a condition known as postoperative ileus, which causes patients to suffer pain, nausea and vomiting. However, stimulation of the nerve, which specifically works through nAChR and STAT3, prevents inflammation of the intestine after surgery. Hence, therapies aimed at tickling nerves might provide new clinical avenues to treat postoperative ileus and other inflammatory conditions.

Author contact:

Wouter de Jonge (Academic Medical Center, Amsterdam, The Netherlands)
E-mail: w.j.dejonge@amc.uva.nl

Additional contacts for comments:

Kevin J. Tracey (North Shore - Long Island Jewish Health System, Manhasset, NY, USA)
E-mail: kjtracey@sprynet.com

Christine N. Metz (The Picower Institute for Medical Research, Manhasset, NY, USA)

E-mail: cmetz@picower.edu

Also published online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.