home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A Selective Gene-Repression Probe

  July, 26 2005 11:09
your information resource in human molecular genetics
Researchers have identified a small-molecule inhibitor that may be a valuable tool for gene-repression studies, according to a paper in Nature Chemical Biology’s August issue. Certain disease states, including cancer and neurodegenerative diseases, have been associated with irregularities in gene-repression.

The mature state of a cell is determined by its specific pattern of gene expression, which in turn is established and maintained by how DNA is packaged into DNA-protein bundles, called chromatin. The nucleosome, the basic unit of chromatin, consists of DNA wrapped around four core histone proteins. The addition of methyl groups to histone proteins is known to play an important role in establishing stable gene expression patterns and is coordinated by histone methyltransferase enzymes. Imhof and colleagues have identified from a panel of small molecules a fungal metabolite, chaetocin that specifically inhibits a class of this enzyme responsible for the methylation of histone H3. The authors demonstrate the efficacy of chaetocin both in vitro and in vivo.

Chaetocin could be a powerful tool for studying histone methylation-mediated gene repression, misregulation of which has been associated with various diseases.

Author contact:

Axel Imhof (Ludwig-Maximillians University of Munich, Germany)
E-mail: imhof@lmu.de

Also published online.

(C) Nature Chemical Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.