A study in the July 2005 issue of Nature Genetics reports a new mechanism underlying motor neuron disease, which may be broadly relevant to several adult-onset neurodegenerative diseases, including amyotrophic lateral sclerosis, Huntington disease, Parkinson disease and Alzheimer disease.
Mutations in the gene encoding dynein, a molecule involved in transporting cargo in neuronal cells, had previously been shown to cause motor neuron disease. David Rubinsztein and colleagues now show that reduced dynein function impairs the clearance of protein aggregates from affected neurons. These aggregates (also called inclusions) are a common feature of several neurodegenerative diseases, and are possibly toxic to the cells. The authors suggest that dynein may normally be responsible for transporting the aggregate-clearing protein complex to its proper location in the neuron.
David Rubinsztein (Cambridge Institute for Medical Research, UK)
Also published online.
(C) Nature Genetics press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...