The relation between sample sizes and statistical power is a constant issue in human molecular genetics. This relationship is not a simple one and is affected by several factors, such as number of statistical tests carried out and LD between markers. Idan Menashe et al presents in a recent paper in BMC Genetics a new freely-available program to calculate statistical power for distinct types of association studies. PGA is a program that is designed to give calculations of samples sizes required for specific statistical power values under different models, such as dominant, co-dominant or recessive effects for single SNPs or haplotypes, and for different study parameters (such as disease prevalences or allele frequencies). In addition, it is possible to obtain a minimum detectable relative risk for specific samples, which is useful for retrospective analysis of previously collected datasets.
PGA will be helpful, in addition to other available programs, such as the Power Genetic Calculator, for researchers designing and analyzing genetic association studies for a large number of human diseases and phenotypes.
Author: Idan Menashe
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, USA
Menashe I, Rosenberg PS, Chen BE. PGA: power calculator for case-control genetic association analyses. BMC Genet. 2008 May 13;9:36.
Paper available online.
The PGA program is available at PGA website.
Message posted by: Diego Forero
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...