home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Preventing Amyloid Formation

  June, 12 2008 8:58
your information resource in human molecular genetics

Epigallocatechin gallate, an antioxidant popularly known as EGCG, can prevent the formation of amyloid fibrils, toxic protein aggregates associated with Alzheimer's and Parkinson's diseases. The findings, published online in Nature Structural & Molecular Biology, may pave the way for the development of more potent compounds designed to prevent amyloid formation associated with several neurodegenerative diseases.

The accumulation of amyloid fibrils in disorders such as Alzheimer's and Parkinson's are believed to be caused by the misfolding and aggregation of certain unfolded proteins, which can be toxic to cells and lead to neurodegeneration. Erich Wanker and colleagues show that EGCG, a compound found abundantly in green tea, can bind to these natively unfolded proteins and prevent their conversion to toxic amyloid species. Instead, EGCG directs them to 'off-pathway' aggregates that are non-harmful to cells.

Because the authors found that EGCG also binds to unfolded proteins not associated with these diseases, future work could be directed to design compounds that specifically recognize the proteins linked to amyloid formation.

Author contact:

Erich Wanker (Max Delbrueck Center for Molecular Medicine, Berlin, Germany)
E-mail: ewanker@mdc-berlin.de

Abstract available online.

(C) Nature Structural & Molecular Biology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.