home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Dialling Down 'Natural' Antibody Production

  June, 27 2007 8:55
your information resource in human molecular genetics
Researchers have identified a molecule that reduces production of antibodies by a specialized set of immune cells reports a paper online in Nature Immunology.

Lars Nitschke and colleagues discovered Siglec-G (sialic acid binding immunoglobulin-like lectin), is highly expressed in a subset of antibody-producing cells called B1 B cells. These cells arise early in life and produce weak antibodies, often called 'natural' antibodies that can recognize many different antigens including 'self-tissues'. Siglec-G acts to desensitize these B1 cells by damping down signalling pathways within these cells when triggered by antigen contact. Mice lacking Siglec-G have higher numbers of B1 cells and substantially more 'natural' antibodies in their blood, including autoantibodies known as rheumatoid factors. Thus, Siglec-G acts as a brake to reduce the potential for excessive antibody production.

The findings point to a possible risk factor for developing autoimmunity disease should mutations arise in the gene encoding Siglec-G that alter its function.

Author contact:

Lars Nitschke (University of Erlangen, Germany)
E-mail: nitschke@biologie.uni-erlangen.de

Abstract available online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.