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The first comparative study of a large number of human embryonic stem (hES) cell lines is reported online in Nature Biotechnology. Conducted by the International Stem Cell Initiative (ISCI), the study examines 59 hES cell lines from 17 laboratories in the United States, Europe, Israel, Japan and Australia. Although the 59 lines were derived using different methods from embryos with diverse genotypes, they proved very similar with regard to the expression of genes and proteins commonly used to identify hES cells.
Many laboratories around the world work with hES cell lines using various experimental techniques, and scientists do not understand the extent of the similarities and differences among the lines. As this technology moves closer to clinical application, it will be important to develop more standardized and reproducible methods for deriving, culturing and characterizing hES cells. The ISCI is seeking to address this challenge through an international collaboration of unprecedented scale. The present report covers the first phase of their ongoing effort. Author contact: Peter Andrews (University of Sheffield, UK)
E-mail: p.w.andrews@shef.ac.uk Additional contact for comment on paper: George Daley (Children's Hospital Boston, Boston, MA, USA)
E-mail: george.daley@childrens.harvard.edu Abstract available online. (C) Nature Biotechnology press release.
Message posted by: Trevor M. D'Souza
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