home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Tracing PRION Traces

 
  June, 14 2001 19:00
your information resource in human molecular genetics
 
     
At present, diseases like scrapie, BSE and its human counterpart, new variant Creutzfeldt Jackob disease (vCJD) can be diagnosed only by post-mortem examination of brain tissue for evidence of faulty prions – the rogue proteins suspected of causing the disease. This is because prions accumulate solely in the brain and are present only at very low concentrations elsewhere in the body.

In this week's Nature (Vol. 411, No. 6839, 14 Jun 2001), Claudio Soto and colleagues at the Serono Pharmaceutical Research Institute in Geneva, Switzerland, report that minute amounts of abnormal prion protein can convert large amounts of normal prion into its faulty state, thereby lowering the threshold of detection considerably. Because trace amounts of abnormal prion are suspected to be circulating in the blood of infected animals or people, the technique could in principle form the basis of a sensitive test for prion diseases.

The method could also be used to produce large amounts of infectious prion protein in vitro (something not possible at present). This would allow the infectivity and pathogenicity of prions to be studied better than is currently possible, the researchers claim.

CONTACT:

Nick Miles (Serono S.A. communications office)
tel +41 22 739 3600
e-mail nick.miles@serono.com

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.