home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Breakdown in Cell's DNA-Proofreading Machinery Prevents Telomere Shortening

 
  June, 12 2001 17:49
your information resource in human molecular genetics
 
     
BAD COPYING EXTENDS CELL LIFE

One way for a cell to become cancerous is to prevent the shortening of its telomeres, the repetitive DNA sequences at the ends of chromosomes that normally decrease in length each time the cell divides, leading to senescence and death. Aylin Rizki and Victoria Lundblad of Baylor College of Medicine, Houston, Texas, have found that, in yeast, this can happen because of a breakdown in the cell's DNA-proofreading machinery (Nature, Vol. 411, No. 6838, 07 Jun 2001).

The researchers looked at yeast strains lacking the genes that normally prevent errors in DNA copying and exchange between chromosomes. These cells could survive indefinitely by swapping non-matching sequences of DNA, thereby maintaining the length of their telomeres. This may be another mechanism by which human cells proliferate, in addition to the reactivation of telomerase (the telomere-building enzyme). It may also have implications for anti-cancer drugs aimed solely at telomerase.

In an accompanying News and Views article, Raju Kucherlapati of the Albert Einstein college of Medicine, New York, and Ronald DePinho of the Harvard Medical School, Boston, describe the research as "a prime example of how studies of yeast guide our understanding of complex human diseases".

CONTACT:

Victoria Lundblad
tel +1 713 798 3454
e-mail lundblad@bcm.tmc.edu

Raju Kucherlapati
tel +1 718 430 2069
e-mail kucherla@aecom.yu.edu

Ronald DePinho
tel +1 617 632 6085/6091
e-mail Ron_Dephinho@Dfci.Harvard.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.