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Diverse Patterns Of Somatic Mutations In Human Breast Cancer Identified

  May, 31 2005 10:49
your information resource in human molecular genetics
Paper title: A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Authors: Philip Stephens et al.

Journal: Nature Genetics, June 2005.

The coding sequences of 518 protein kinases in 25 breast cancers were examined. In many tumors, no somatic mutations were detected. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

The results indicate that a previously hidden diversity of mutational processes exists in breast cancer.

Author contact:

Michael R Stratton
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

E-mail: mrs@sanger.ac.uk

Also available online.

(C) Nature Genetics.

Message posted by: Trevor M. D'Souza

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