Paper title: A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Authors: Philip Stephens et al.
Journal: Nature Genetics, June 2005.
The coding sequences of 518 protein kinases in 25 breast cancers were examined. In many tumors, no somatic mutations were detected. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
The results indicate that a previously hidden diversity of mutational processes exists in breast cancer.
Michael R Stratton
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Also available online.
(C) Nature Genetics.
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