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Paper title: A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Authors: Philip Stephens et al. Journal: Nature Genetics, June 2005. The coding sequences of 518 protein kinases in 25 breast cancers were examined. In many tumors, no somatic mutations were detected. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure. The results indicate that a previously hidden diversity of mutational processes exists in breast cancer. Author contact: Michael R Stratton
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. E-mail: mrs@sanger.ac.uk Also available online. (C) Nature Genetics.
Message posted by: Trevor M. D'Souza
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