home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A New Mechanism Behind Atherosclerosis

  May, 31 2005 10:46
your information resource in human molecular genetics
Smoking and elevated cholesterol levels have been shown to increase vascular disease, but these risk factors are absent in many cases. Now, a study appearing in the 26 May 05 issue of Nature (Vol. 435, No. 7041, pp. 502-506) offers proof of another mechanism behind atherosclerosis, a type of vascular disease. The study finds that abnormal metabolism in arterial walls can cause this disorder.

Clay Semenkovich and colleagues designed mice that overexpressed a gene involved in energy production from respiratory oxygen in vascular tissue, thereby disrupting the process. This caused a rise in oxidative stress in arterial walls, leading, in turn, to a rise in blood pressure and atherosclerosis. The authors suggest that nutritional strategies might be designed around this newly discovered mechanism to help fight heart disease in patients.


Clay F. Semenkovich (Washington University School of Medicine, St Louis, MO, USA)
E-mail: csemenko@im.wustl.edu

(C) Nature

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.