Multi-talented bone - it is dynamic, strong and resilient. It offers a home to bone marrow and a protective cage for vital organs. It balances growth and repair without overgrowth. Yet an estimated 200 million women worldwide are affected by osteoporosis, and each year the US spends $14 billion treating osteoporotic fractures.
An Insight in this week's Nature presents a collection of articles that explore key elements of skeletal biology, including the influence of genetics on human skeletal biology, bone and cartilage development, signalling pathways that control bone mass, and the pathology of rheumatoid arthritis.
 The complexities of skeletal biology - G. Karsenty
 Deciphering skeletal patterning: clues from the limb - F. V. Mariani & G. R. Martin
 Cranial skeletal biology - J. A. Helms & R. A. Schneider
 Developmental regulation of the growth plate - H. M. Kronenberg
 Osteoclast differentiation and activation - W. J. Boyle, W. S. Simonet & D. L. Lacey
 The genetic basis for skeletal diseases - E. Zelzer & B. R. Olsen
 Control of osteoblast function and regulation of bone mass - S. Harada & G. A. Rodan
 Evolving concepts of rheumatoid arthritis - G. S. Firestein
(C) Nature press release.
Message posted by: Trevor M. D'Souza