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Multi-talented bone - it is dynamic, strong and resilient. It offers a home to bone marrow and a protective cage for vital organs. It balances growth and repair without overgrowth. Yet an estimated 200 million women worldwide are affected by osteoporosis, and each year the US spends $14 billion treating osteoporotic fractures.
An Insight in this week's Nature presents a collection of articles that explore key elements of skeletal biology, including the influence of genetics on human skeletal biology, bone and cartilage development, signalling pathways that control bone mass, and the pathology of rheumatoid arthritis.
[1] Introduction [2] The complexities of skeletal biology - G. Karsenty [3] Deciphering skeletal patterning: clues from the limb - F. V. Mariani & G. R. Martin [4] Cranial skeletal biology - J. A. Helms & R. A. Schneider [5] Developmental regulation of the growth plate - H. M. Kronenberg [6] Osteoclast differentiation and activation - W. J. Boyle, W. S. Simonet & D. L. Lacey [7] The genetic basis for skeletal diseases - E. Zelzer & B. R. Olsen [8] Control of osteoblast function and regulation of bone mass - S. Harada & G. A. Rodan [9] Evolving concepts of rheumatoid arthritis - G. S. Firestein
(C) Nature press release.
Message posted by: Trevor M. D'Souza
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