home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Blood Stem Cell Signalling

 
  May, 5 2003 9:21
your information resource in human molecular genetics
 
     
The signalling molecule Wnt has been purified. Wnt proteins may help blood stem cells to divide and self-renew, according to two papers published online by Nature.

Wnt signalling is involved in many events in animal development, and has been implicated in some human cancers. Now Roel Nusse from Stanford University School of Medicine, California, and colleagues have isolated active, pure Wnt proteins for the first time. They find that the proteins have a fat molecule attached, which is essential for the activity of Wnt. The purified protein also prompts blood-forming stem cells in the bone marrow to divide and make new copies of themselves.

Tannishtha Reya from Duke University Medical Center, North Carolina, and colleagues reach a similar conclusion. They also find that blood stem cells expressing Wnt pathway inhibitors fail to divide in culture and after they have been injected into mice.

These and other studies suggest that Wnt may signal a diverse range of tissues to self-renew. Understanding how molecular signals influence stem cells may help researchers to harness the potential of signalling molecules like Wnt as a therapeutic transplant source.

Author contacts:

Roel Nusse
Howard Hughes Medical Institute and Dept of Developmental Biology
Stanford University School of Medicine
Stanford, CA
USA
Tel: +1 650 723 7769
E-mail rnusse@cmgm.stanford.edu

Tannishtha Reya
Dept of Pharmacology & Cancer Biology
Duke University Medical Center
Durham, NC
USA
Tel: +1 919 613 8756
E-mail t.reya@duke.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.