home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Light Switch for Brain Signalling Pathways

  April, 3 2009 2:32
your information resource in human molecular genetics

A new method uses light to turn specific intracellular signalling pathways on and off in live, behaving animals. The technique, described in Nature, should prove useful for neuroscience research, providing an insight into the links between signalling systems and behaviour.

Karl Deisseroth and colleagues devised a versatile family of genetically encoded optical tools (optoXRs) that can control the activity of G-protein-coupled receptor signalling pathways, a diverse family of signalling pathways that responds to certain hormones, neurotransmitters, pheromones and other chemicals. The response is fast and, in turn, influences neuronal activity.

The team has demonstrated proof of principle in live mice where they used light to activate the molecules and stimulate specific neurons in a particular part of the brain linked to reward, driving a conditioned behavioural response for place preference.


Karl Deisseroth (Stanford University, CA, USA)
E-mail: deissero@stanford.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.