home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Genes Linked To Chemotherapy Response

  April, 19 2007 8:16
your information resource in human molecular genetics
Scientists have identified a number of genes in lung cancer cells which, when downregulated, make the cancer cells especially vulnerable to a type of chemotherapy.

The study, reported in April 12, 2007 issue of Nature (Vol. 446, No. 7137, pp. 815-819), highlights a new way to screen for alterations in cancer cells that make them specifically sensitive to therapeutics, so that treatment may leave normal tissue relatively unharmed.

Michael A. White and colleagues used a genome-wide RNA interference screen to identify 87 genes that are involved in the response of cancer cells to paclitaxel. Reducing the expression of a number of these genes sensitizes lung cancer cells to paclitaxel at concentrations 1,000-fold lower than otherwise needed for a significant response. Some of the identified genes are already targets of currently available compounds and could be tested for responses to combinations of drugs, whereas others could be new therapeutic targets.


Michael A. White (University of Texas Southwestern Medical Center, Dallas, TX, USA)
E-mail: michael.white@utsouthwestern.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.