home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Genes Set Scene For Metastasis

  April, 19 2007 8:14
your information resource in human molecular genetics
Biologists have identified a set of genes expressed in human breast cancer cells that work together to remodel the vasculature at the site of the primary tumour and that also promote the spread of cancer to the lungs.

The finding, reported in the April 12, 2007 issue of Nature (Vol. 446, No. 7137, pp. 765-770), helps to explain how cancer metastasis can occur and highlights targets for therapeutic treatment.

Metastasis is the leading cause of mortality in cancer patients. A number of genes are already known to contribute to the spread of breast cancer cells to the lungs. But Joan Massague and colleagues now show how four genes cooperate to promote the formation of new tumour blood vessels, the release of cancer cells into the bloodstream, and the penetration of tumour cells from the bloodstream into the lung.

The gene set comprises EREG, MMP1, MMP2 and COX2; drug combinations that target more than one of these components may prove useful for treating metastatic breast cancer.


Joan Massague (Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, New York, NY, USA)

Please contact:

Esther Napolitano (Public Affairs, Memorial Sloan-Kettering Cancer Center, New York, NY, USA)
E-mail: napolite@mskcc.org

Gerhard Christofori (University of Basel, Switzerland)
E-mail: gerhard.christofori@unibas.ch

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.