home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Anti-Cancer Barrier Found

 
  April, 19 2005 10:06
your information resource in human molecular genetics
 
     
In the 14 April 2005 issue of Nature (Vol. 434, No. 7035), two papers (pp. 864-870, 907-913) offer insights into how cells can fight off the earliest stages of cancer.

Biologists have wondered why human cancer is not more frequent, given the trillions of susceptible cells and the countless mutations that could potentially trigger uncontrolled cell proliferation. One intensely debated idea is that cells usually recognize and stop abnormal division.

Teams led by Jiri Bartek and Thanos Halazonetis now show that cells in very early stage human cancers from different tissues (including bladder, breast, colon and lung) activate a series of events involved in recognizing and repairing DNA damage. These include activation of the tumour suppressor protein p53. They suggest that aberrant cell division at the earliest stages of carcinogenesis triggers DNA damage - and that the cell responds by activating a programme of DNA repair that arrests cell division and can trigger cell death.

The authors suggest that uncontrolled cell division somehow upsets the DNA replication process so that mistakes are introduced. Their results suggest why mutations that disable the DNA repair process, such as p53 mutations, are commonly associated with cancer and help it to progress.

CONTACT

Jiri Bartek (Institute of Cancer Biology, Copenhagen, Denmark)
E-mail: jb@cancer.dk

Thanos Halazonetis (The Wistar Institute, Philadelphia, PA, USA)
E-mail: halazonetis@wistar.upenn.edu

Ashok R. Venkitaraman (University of Cambridge, UK)
E-mail; arv22@cam.ac.uk

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.